Interdisciplinary
Biomedical Graduate ProgramInterdisciplinary
Biomedical Graduate ProgramThe Projects
Ahearn,
Joseph, Vaccine development, immune tolerance, autoimmunity, viral
tropism
Albers,
Kathryn, Transgenic mouse models to study growth factor regulation
of sensory system development and function
Apodaca,
Gerard, Regulation of endocytic traffic in polarized epithelial cells
Aridor,
Meir, Molecular mechanisms of cargo sorting in the early secretory
pathway: role in diseases development
Bahar,
Ivet, Computational analysis of biomolecular structure and dynamics;
simulations
of complex biomedical processes; statistical analysis of biological
databases
Balaban,
Carey, Molecular mechanisms for plasticity in the vestibular system
Barranger,
John A., Molecular genetics of inherited lysosomal disorders
Barratt-Boyes,
Simon, Dendritic cell biology and SIV infection in non-human primates
Becker,
Dorothea, Molecular analysis of genes governing melanoma development
and progression
Bowser,
Robert, Alternative expression and function of transcriptional regulators
and
apoptotic gene products during neurodegeneration
Bradbury,
Neil, Endocytosis, Protein Traffic and Human Disease
Cascio,
Michael, Structure and function of human glycine receptor; computational
studies of
T cell receptor-mucin interaction and metalloendoproteinase structure
Chaillet,
J. Richard, Genomic imprinting and the control of stem cell differentiation
Cheng,
Shi-Yuan, Molecular mechanisms of tumor angiogenesis
Chu,
Charleen, T., Molecular mechanisms of neurodegeneration: Oxidative
stress and cell signaling
Clemens,
Paula, Gene Transfer to Muscle
Davis,
Brian M., Development and plasticity of the sensory nervous system
with an emphasis on visceral and somatic pain.
Day,
Billy, Discovery of novel microtubule perturbing agents; Mass spectrometric
molecular dosimetry
DeFranco,
Donald B., Signaling Pathways Regulating Neuronal Cell Survival/Subcellular
Trafficking of Nuclear Hormone Receptors
DeLuca,
Neal, Herpes virus-host cell interactions
Delude,
Russell, Molecular mechanisms of RAGE signal transduction
Devor,
Dan, Our laboratory is interested in the molecular mechanisms underlying
the regulation and trafficking of members of the calcium-dependent potassium
channel gene family, SK1-4.
Dorman,
Janice, molecular epidemiology of autoimmune diseases and their impact
on women's health
Ermentrout,
Bard, Neural oscillations
Fabisiak,
James P., Interactions between chemopreventive antioxidants/nutritional
micronutrients and cellular redox homeostasis.
Feingold,
Eleanor, genetic epidemiology of Down syndrome, statistical methods
for genetic mapping, and analysis of
large-scale gene expression data.
Ferrell,
Robert, Genetics of common diseases
Flynn,
JoAnne, Immunology of infectious disease: in particular Tuberculosis
Friedman,
Peter A., Studies in our lab focus on the mechanism and regulation
of calcium transport by parathyroid hormone (PTH).
Frizzell,
Raymond, Molecular and genetic mechanisms regulating ion channel trafficking
and activity
Galbiati,
Ferruccio, The work in Dr. Galbiati’s laboratory is focused on investigating
the role of caveolae and caveolins in muscular dystrophy and cancer.
Gandhi,
Chandrashekhar, Role of stellate cells in hepatic pathophysiology
Getzenberg,
Robert, Nuclear Structure as a Target for Cancer Diagnostics and Therapy
Gollin,
Susanne M., The mechanisms behind chromosomal instability and gene
amplification in cancer cells
Gorin,
Michael, Genetics of hereditary eye disorders, including retinal dystrophies,
myopia and age-related macular degeneration and cataracts
Grabowski,
Paula J., Alternative RNA splicing in the nervous system
Graham,
Steven, Genetic control of neuronal cell death in ischemia and other
neurological diseases
Grandis,
Jennifer Rubin, Growth factor receptors in cancer: targeting signal
transduction mechanisms
Grant,
Stephen, Genetic predisposition to and environmental induction of cancer
Hastings,
Teresa G., Protein modification and oxidative damage in neurodegenerative
diseases
Hebda,
Patricia, In vitro systems to grow and study upper airway mucosal cells
and tissues
Hendricks,
Robert, T Lymphocyte responses in virus infected tissues
Homanics,
Gregg, Genetically altered mice: investigations into alcohol/ anesthetic
action and disease models
Horn,
John P., Synaptic mechanisms of neural computation in sympathetic ganglia
Huang,
Leaf, Delivery of drugs and genes for therapy
Huard,
Johnny, Muscle derived stem cells biology and their potential use in
gene therapy and tissue engineering applications for Musculoskeletal Tissue
regeneration
Hughey,
Rebecca, Regulation of protein trafficking at the apical surface of
polarized epithelial cells
Jackson,
Edwin K., Cardiovascular and renal pharmacology.
Jenkins,
Frank, Epidemiology and Pathogenesis of Human Herpes Virus 8 (HHV-8).
Jiang,
Yu, We are interested in the signaling mechanism by which Tor
mediates cell growth and proliferation.
Johnson,
Candace, Steroid Hormones: Therapeutic Efficacy
Johnson,
Daniel, E., Molecular Mechanisms Regulating Apoptosis and Blood Cell
Differentiation
Kagan,
Valerian, Chemoprevention of oxidative stress
Kalinski,
Pawel, Role of dendritic cells in the induction of TH1 and TH2 responses:
implications for immunotherapy and pathology.
Kamboh,
M. Ilyas, Genetics of common diseases, including coronary heart disease,
lupus and Alzheimer's disease.
Kandler,
Karl, Development and plasticity of inhibitory connections
Katyal,
Sikandar, Molecular Mechanisms of Lung Development and Repair
Khan,
Saleem, Human papillomaviruses: replication and gene therapy;
DNA replication
in Staphylococcus aureus
Kinchington,
Paul (Kip), Molecular Control by the herpesvirus Varicella Zoster Virus
Klarlund,
Jes K., Signaling in cell migration
Klein-Seetharaman,
Judith, Sequence-structure-function relationships in proteins
Kleyman,
Thomas, Cellular and molecular biology of epithelial ion channels
Koty,
Patrick, Translational genetic approaches to lung cancer prevention
and treatment
Latimer,
Jean, The loss of DNA repair and breast cancer etiology
Lazo,
John, One major goal of our laboratory is to understand the role dual
specificity phosphatases have in controlling cell cycle checkpoints and
cell survival.
Levitan,
Edwin, Regulation of ion channels and neuropeptide release
Liu,
Youhua, Regulation and mechanism of renal regeneration and fibrosis
Luisi-Deluca,
Cynthia, Function of RecO protein in recombination and repair E. coli
McCarthy,
Susan, Regulation of cytolytic T lymphocyte development and apoptosis
McClane,
Bruce, The pathogenesis of Clostridium perfringens
Mars,
Wendy, Interactions between the urokinase-type plasminogen activator,
hepatocyte growth factor and their various receptors.
Mellors,
John, Human immunodeficiency virus type 1 (HIV-1) and antiretroviral
therapy with specific emphasis on the genetics, biochemistry, structural
basis and clinical significance of antiretroviral drug resistance
Michalopoulos,
George, Regulation of growth and differentiation of hepatocytes by
Hepatocyte Growth Factor (HGF)
Milcarek,
Christine, The role of RNA processing in B-cell development and differentiation
Monaghan-Nichols,
Paula, genetic basis of behaviour and how alteration during development
lead to behavioural abnormalities
Montelaro,
Ron, Molecular biology and immunology of HIV-1 and related animal lentiviruses
Moore,
Patrick, Our laboratory studies basic mechanisms of healthy cell transformation
into cancer cells during viral oncogenesis
Morel,
Penelope, Dendritic cells in autoimmunity /Regulation of Th1/Th2 responses/
Human NK cell function in health and disease
Morris,
Sid, Penile erection; regulation of transcription and metabolism
in inflammation
Murphey-Corb,
Michael, pathogenesis of SIV and development of DNA vaccines for the
induction of mucosal immunity
Murray,
Sandra, Role of cell communication in endocrine cell behavior
Narayanan,
Vinodh, neural cell adhesion molecules; neurogenetics
Nichols,
Mark, Estrogen receptor function and breast cancer
Nimgaonkar,
Vishwajit, Genetic epidemiology of schizophrenia and bipolar disorder
Norris,
Karen, immunology and pathogenesis of two eukaryotic pathogens, Trypanosoma
cruzi and Pneumocystis carinii
Onate,
Sergio, Mechanism of Steroid Hormone Action And Tumor Biology
Oury,
Tim D., Oxidative mechanisms in pulmonary, vascular, and neurodegenerative
diseases
Parniak,
Michael A., HIV biochemistry and structural biology, identification
and characterization of novel antiviral agents, and molecular mechanisms
of HIV antiviral drug resistance.
Perel,
James M., Molecular and chemical features of mechanisms of drug actions
in humans
Pitt,
Bruce R., Molecular pharmacology of lung with focus on effects of oxidative
and nitrosative stress on pulmonary endothelium and smooth muscle.
Plant,
Tony, Physiological and cellular regulation of stem cell and spermatogonial
renewal in the primate testis.
Plevy,
Scott, Molecular regulation of cytokine gene expression and mucosal
immunity.
Prochownik,
Edward , Myc oncogenes and their transcriptional targets.
Rajasekaran,
Baskaran, DNA Damage Cell Signaling: Cell Cycle Regulation and Growth
Control
Ray,
Anuradha, T cell/Dendritic Cell Differentiation and Signaling in Allergic
Lung Disease and Tolerance
Ray,
Prabir, Inducible Transgenic Modeling of Lung Diseases
Reynolds,
Ian, Signalling mechanisms in neurodegeneration
Reynolds,
Paul R., Pulmonary Genomics and Proteomics
Ridgway,
William M., Immunogenetic control of autoimmunity, T cell tolerance,
autoimmune diabetes
Rinaldo,
Charles, T cell immunity to human immunodeficiency virus and human
herpesvirus type 8
Robbins,
Paul D, Gene therapy for autoimmune diseases and cancer
Romero,
Guillermo, Regulation of phospholipase D by tyrosine kinase receptors
Romkes,
Marjorie, Pharmacogenomics and Biomarkers of Susceptibility
Sahu,
Abhiram, Neurobiology of food intake and body weight regulation: the
mechanism of
leptin signaling in the hypothalamus
Salama,
Guy, Optical mapping of electrical activity in excitable syncytia;
Regulation of Intracellular Calcium in heart and skeletal muscle; Mechanisms
of action of Nitric Oxide on Intracellular Calcium Handling
Salter,
Russell, Antigen processing in dendritic cells; Autoimmune responses
in rheumatoid arthritis
Schmidt,
Martin, Characterization of protein interactions with the yeast glucose
sensors
Schor,
Nina, Design of novel therapies for neural crest tumors; apoptosis
induction in
the neural crest
Shurin,
Michael R., Tumor Immunology, Molecular Mechanisms of tumor-induced
immunosuppression of dendritic cells
Siegfried,
Jill, The role of gastrin-releasing peptide receptor in the development
of lung cancer.
Smithgall,
Tom, Non-receptor protein-tyrosine kinases: Regulation of kinase activity
and
downstream signal transduction
Steinman,
Richard, Our laboratory investigates the control of stem cell cycling
and mechanisms coupling differentiation and cell cycle arrest.
Stewart,
Alex, Identification of the non-AUG initiator of the transcription
factor DTEF-1
Stolz,
Donna, Angiogenesis during liver regeneration
Stripp,
Barry R., Stem cell maintenance and differentiation in airway
homeostasis.
Sved,
Alan F., Central neural control of autonomic function, particularly
blood pressure
Tang,
Pei, Computational and spectroscopic approaches to drug and protein
interactions
Thomson,
Angus, Dendritic cells in transplantation tolerance
Traub,
Linton, Molecular dissection of the role of clathrin-coated vesicles
in intracellular
membrane trafficking
Trucco,
Massimo, Genetics and immunogenetics of human histocompatibility antigens;
etiology, prevention, and cure of autoimmune diseases (e.g., type 1
diabetes).
Vujanovic,
Nikola, Role of TNF family ligands and their receptors in immune destruction
and escape of cancer
Walker,
William, Gene Regulation in Mammalian Spermatogenesis
Wang,
Zuo-Zhang, Protein-protein interactions mediating synapse formation
and development
Weeks,
Daniel E., Statistical methods for genetic mapping of complex diseases
Wells,
Alan, The role of cell migration in physiologic and pathologic conditions.
Weisz,
Ora, Regulation of apical membrane traffic
Whiteside,
Theresa L., Our laboratory studies immunobiology and immunotherapy
of human cancer, specifically, of oral carcinoma.
Wiley,
Clayton, Macrophage mediated neurodegeneration in AIDS
Wu, Chuanyue
(Cary), Cell Adhesion and Signal Transduction
Xiao,
Xiao, adeno-associated virus vectors in vivo gene therapy for neuromuscular
diseases, cancer and arthritis
Xu, Yan,
Understanding the structural basis of protein function
Yalowich,
Jack, Mechansisms of action and resistance to DNA Topoisomerase II-targeted
anticancer agents; Cancer chemoprevention.
Yin,
Xiao-Ming, Dissecting the molecular pathways of programmed cell death
(apoptosis)
Zhan,
Qimin, The control of Cell cycle progression and related signaling
pathways.
Zarnegar,
Reza, Tissue growth and transcriptional control
Zigmond,
Michael J., Neurobiology of stress and neurodegenerative disease
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